Add to cart. Infection triggers cell cycle arrest and the DNA damage response pathway, as well as a general host immune response that targets infected cells. 0000003074 00000 n

MVM(p) infects fibroblasts, whereas MVM(I) infects T lymphocytes.MVM is of special concern for laboratory mouse colonies. Although evidence of infection with Seoul virus has been found in Norway rats throughout much of the world, including the United States, human disease caused by Seoul virus is largely restricted to Asia.

Contact with infected fomites, such as food and water bowls or bedding, can also spread MVM.As a parvovirus, MVM is resistant to a range of disinfectants. Unlike the situation in rebuilding a colony after eliminating some other rodent viruses, colonies that have had parvovirus infections cannot always be repopulated by cesarean section and use of foster mothers.

Printer friendly. Please inquire about quantity discounts. Young animals born from infected dams are protected by maternal antibody for the first few weeks of life, but then are infected via the oronasal route. Enter your e-mail and subscribe to our newsletter. Admission of biological materials must be restricted to samples that have been tested and found free from viral contamination.Both allotropic variants of MMV have been used as models for molecular virology, and their small size and simple structure have facilitated examination of their molecular biology and expedited understanding of cell tropism, viral genetics, and structure. Kilham rat virus Klebsiella pneumoniae. “Activation of an Antiviral Response in Normal but Not Transformed Mouse Cells: A New Determinant of Minute Virus of Mice Oncotropism  .” Marchini, Antonio et al. 0000041138 00000 n

MVM is a common infection in laboratory micedue to its highly contagious nature. In experimental colonies, elimination of infected animals and subsequent replacement with uninfected mice is practical if careful environmental sanitation is conducted by appropriate disinfection procedures. MVM was shown to be susceptible to 2% glutaraldehyde, 0.55% ortho-phthaldehyde, 0.2% peracetic acid, and 2500 ppm sodium hypochlorite.Baker, David G. "Natural pathogens of laboratory mice, rats, and rabbits and their effects on research."

“Oncolytic Parvoviruses: From Basic Virology to Clinical Applications.”

The sequences differed by up to 5% and also differed in the highly variable region (Experimental MVM infections in immune-deficient mice using molecularly cloned virus stocks showed emergence of variation over a period of days or weeks (Adeno-associated viruses show sequence diversity both within hosts and within the population. Reference reagents are used to identify particular virus strains, or viral DNA can be identified by PCR and the specific virus type determined by DNA sequencing. MVM infection does not typically cause symptoms in healthy adult mice. Fischer rat fibroblasts, naturally resistant to killing by the fibrotropic strain of minute virus of mice [parvovirus MVM(p)], became sensitive to MVM when transformed by polyomavirus. ScienceDirect ® is a registered trademark of Elsevier B.V.URL: https://www.sciencedirect.com/science/article/pii/B9780122639517500326URL: https://www.sciencedirect.com/science/article/pii/B9780124095274000031URL: https://www.sciencedirect.com/science/article/pii/B9780123820082000192URL: https://www.sciencedirect.com/science/article/pii/B9780123364258500765URL: https://www.sciencedirect.com/science/article/pii/B978012409527400033XURL: https://www.sciencedirect.com/science/article/pii/B9780124375512500045URL: https://www.sciencedirect.com/science/article/pii/B9780123741530000175URL: https://www.sciencedirect.com/science/article/pii/B9780123809209000535URL: https://www.sciencedirect.com/science/article/pii/B9780124047303000269URL: https://www.sciencedirect.com/science/article/pii/B978012800946800012XMark T. Whary DVM, PhD, DACLAM, ... Stephen W. Barthold DVM, PhD, Diplomate ACVP, in Mice minute virus is the type species of the genus Parvovirus. 0000002148 00000 n Mouse mammary tumor virus. 0000008607 00000 n

Etiology: Parvoviruses are single stranded nonenveloped DNA viruses. rat minute virus (RMV). Eterpi, M., G. McDonnell, and V. Thomas.

Rat virus, formerly known as Kilham’s rat virus (RV; KRV) may, albeit rarely, produce disease with natural infections in naïve rats. RMV stands for Rat Minute Virus.



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