13.30-15.30 Selected Abstracts ‚Lower GI‘ 15.30-16.30 ASCO Direct Live Session. margin-bottom: 100px;

Neuroendocrine tumors (NET), first described as “carcinoids” by pathologist Siegfried Oberndorfer, MD, PhD, originate from endodermal neuroendocrine cells and may occur in any site of the body.Effective therapies for gastroenteropancreatic neuroendocrine tumors (GEP-NETs) beyond first-line somatostatin receptor (SSTR) analogs are limited.The 2020 Gastrointestinal (GI) Cancers Symposium, to be held January 23-25 in San Francisco, will feature a weekend full of discussions and updates on esophageal, gastric, anal, colorectal, pancreatic, hepatobiliary cancers, and more.Hepatobiliary cancers (HBC) include a spectrum of aggressive invasive carcinomas arising in the liver (hepatocellular carcinoma), gallbladder, and bile ducts (intrahepatic and extrahepatic cholangiocarcinoma).The 2019 Gastrointestinal (GI) Cancers Symposium held in January, in San Francisco, featured a diverse program showcasing groundbreaking research, updates on current treatment strategies, and plentiful opportunities for attendee interaction and networking.The randomized, double-blind, phase III TAGS trial conducted in 507 patients with metastatic gastric/gastroesophageal junction (G/GEJ) adenocarcinoma who had previously received at least two chemotherapy regimens met its primary endpoint by establishing a 2.1-month improvement in overall survival (OS) with the use of trifluridine/tipiracil versus placebo (HR 0.69, 95% CI [0.56, 0.85]; p = 0.00029).Data from two clinical studies, the phase III KEYNOTE-181 trial and a phase II Memorial Sloan Kettering Cancer Center (MSKCC) trial, lend support to using pembrolizumab-containing regimens in selected patients with advanced esophageal cancer.FOLFOX constitutes a standard of care for the first-line treatment of unresectable locally advanced or metastatic gastric cancer.The Prep-02/JSAP-05 trial conducted in Japan is the first to demonstrate the efficacy of neoadjuvant therapy in resectable pancreatic cancer.Biliary tract cancer (BTC) comprises a heterogeneous collection of rare, aggressive neoplasms, which together carry a very poor prognosis.A subgroup analysis of a large study designed to validate the clinical utility of the Immunoscore Colon suggests that the test can readily identify a large subset of patients with high-risk stage II colon cancer who can forego adjuvant chemotherapy without increasing the risk of recurrence (Abstract 487).Attempts to improve survival outcomes with tecemotide, an antigen-specific cancer vaccine targeting mucin 1 (MUC1), fell short in patients who had stage IV colorectal cancer (CRC) with metastases confined to the liver.Research shows that immune checkpoint blockade works in advanced colorectal cancer (CRC) but heretofore only in patients with high microsatellite instability (MSI-H) or DNA mismatch repair–deficient (dMMR) disease.The standard approach to treating locally advanced rectal cancer in many parts of the world involves 5 to 6 weeks of neoadjuvant chemoradiation followed 6 to 8 weeks later by surgery and then adjuvant multiagent chemotherapy after recovery.Pancreatic ductal adenocarcinoma (PDAC) is on track to be the second leading cause of cancer-related mortality in the United States by 2030.The Japanese ACTS-CC 02 trial, designed to establish the superiority of adjuvant treatment with S-1 plus oxaliplatin (SOX) over UFT (tegafur and uracil) plus leucovorin (LV) in patients with high-risk stage III colon cancer, failed to meet the primary endpoint (Abstract 484).Delivering adjuvant HIPEC to patients with T4 or perforated colon cancer provides no improvement in peritoneal metastasis-free survival (PMFS) when added before standard systemic therapy, according to results of the randomized phase III COLOPEC trial (Abstract 482).A phase I/II study sponsored by the National Cancer Institute (Abstract 192) lends support to further evaluating a potential new treatment strategy in advanced pancreatic adenocarcinoma (aPDAC)—more specifically, one that combines immune checkpoint inhibition and stereotactic body radiation therapy (SBRT).An exploratory analysis of findings from the phase III REFLECT trial (Abstract 186) suggests that an objective response could serve as a surrogate endpoint for prolonged overall survival (OS) in patients with hepatocellular carcinoma (HCC).The large, randomized, double-blind, phase III ATTRACTION-2 trial previously demonstrated that nivolumab yielded significantly better overall survival compared with placebo among 493 patients with gastric or gastroesophageal junction (G/GEJ) adenocarcinoma who were refractory to or intolerant of two or more previous chemotherapy regimens (HR 0.63, 95% CI [0.51, 0.78]; p < 0.0001).The Big Ten Cancer Research Consortium reports early-phase data suggesting that adjuvant treatment with the PD-L1 inhibitor durvalumab helps prevent relapse in patients with locally advanced esophageal or gastroesophageal junction (GEJ) adenocarcinoma (Abstract 5).Andrew S. Kennedy, MD, a radiation oncologist with the Sarah Cannon Research Institute, has been attending the Gastrointestinal Cancers Symposium for 10 years.Minaxi Jhawer, MD, has attended the Gastrointestinal (GI) Cancers Symposium multiple times over the past 10 years.Lucas Wong, MD, FACP, has attended the Gastrointestinal (GI) Cancers Symposium since its inception and hopes to attend its 20th anniversary.Nina Karlin, MD, FACP, of Mayo Clinic Arizona, has attended the Gastrointestinal (GI) Cancers Symposium for 7 years.Khaldoun Almhanna, MD, MPH, of Lifespan Cancer Institute and Brown University, has attended the Gastrointestinal (GI) Cancers Symposium for 13 years.Sessions will include presentations on palliative care and patient advocacy.ASCO’s Research Community Forum (RCF) Annual Meeting on Sept. 23 and 24, 2018, demonstrated how community-focused strategies in clinical research encourage collaboration and improve patient access to clinical trials.
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ASCO-GI 2019 .

display: none!important; Outline • Updates in targeted therapies – Dusty Deming • Standard of Care testing • NTRK • BRAF • HER2 • Updates in immunotherapies – Nataliya Uboha • Immunotherapy for MMR deficient CRC (MSI-H) • Immunotherapy in MMR proficient CRC (MSS) • Immunoscore as a validated prognostic marker

table{ Gastrointestinal Cancers Symposium of the American Society of Clinical Oncology, ASCO GI 2021 will be held in San Francisco, California between 15-17 January 2021. Prof. Efrat Dotan Fox Chase Cancer Center, Philadelphia, USA CANCERS OF THE LIVER, LOWER INTESTINE AND PANCREAS TRACT 2.

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padding-top: 4px; https://www.pr-medicalevents.com/specialty/oncology/Gastrointestinal Cancers Symposium of the American Society of Clinical Oncology, ASCO GI 2021 will be held in San Francisco, California between 15-17 January 2021.PR Medical Events is pleased to support your group with accommodation at preferential rates in our partner hotels during ASCO GI 2021 as well as any other travel related service (on-site assistance, transfers, dinners, city tours).Get the best hotel offers for ASCO GI 2021 in San Francisco A sales representative will call you back within 2 working hours of you submitting this form.A sales representative will call you back within 2 working hours of you submitting this form.Please fill in all of the details and let us know the specifics of your request in the details text field. Cookie Notice.

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