0000699309 00000 n 0000170162 00000 n When combined with targeted antibodies, GDA-201 has shown enhanced antibody-dependent cellular toxicity, or ADCC.GDA-201 is being evaluated in a Phase 1 clinical study in patients with refractory non-Hodgkin lymphoma and multiple myeloma.For more information about the study, please visit Cell-based therapies are recognized for their tremendous potential to provide curative treatment options for patients with blood cancers and rare, serious blood disorders. A carbohydrate-based galectin inhibitor, with potential antineoplastic activity. 0000785851 00000 n %PDF-1.4 %���� 0000700912 00000 n 0000332926 00000 n 0000334543 00000 n What is omidubicel? mechanism of action coming from our target discovery platform. — GDA-201 demonstrated early evidence of clinical activity in patients with non-Hodgkin lymphoma, with multiple complete responses observed — — Research on mechanism of action for the NAM technology platform provides further scientific rationale for stem cell engraftment and patient outcomes reported in previous Phase 1/2 clinical study of omidubicel — 0000002223 00000 n 0000005195 00000 n
However, efforts to create effective treatments to date have been hampered by the inability to expand cells in the laboratory while maintaining therapeutic functionality.At Gamida Cell, we’re pioneering a new approach with the potential to improve treatment outcomes beyond what is possible with donor-derived therapies. 0000710962 00000 n Explore our pipeline below for information on our clinical development candidates and ongoing clinical trials.Omidubicel is an advanced cell therapy under development as a potential life-saving allogeneic hematopoietic stem cell (bone marrow) transplant solution for patients with hematologic malignancies (blood cancers). 0000333836 00000 n 0000337094 00000 n Full safety and efficacy data are anticipated in the second half of 2020, and we intend to initiate the submission of a biologics license application (BLA) filing in the fourth quarter of 2020.For more information about the topline study results, please see Omidubicel is an advanced cell therapy under development as a potential life-saving allogeneic hematopoietic stem cell (bone marrow) transplant solution for patients with hematologic malignancies (blood cancers). 0000669624 00000 n
0000819672 00000 n 0000751952 00000 n
0000000016 00000 n Gamida Cell’s proprietary nicotinamide-based, or NAM-based, expansion technology enables donor cells to grow while maintaining functionality. 0000004498 00000 n
0000003862 00000 n 211 68 0000331866 00000 n Specifically for omidubicel, this research suggests that NAM modulates certain gene expression pathways that, collectively, mimic the hypoxic environment of the bone marrow to help preserve stem cell function and long-term engraftment ability,” said Tracey Lodie, Ph…
Omidubicel is a stem cell therapy composed of umbilical cord-derived ex vivo expanded stem and progenitor cells, being developed by Gamida Cell, as an infusion 0000697654 00000 n
Galectin inhibitor GR-MD-02 binds to the carbohydrate-binding domain of galectins, especially galectin-3, and may result in an induction of apoptosis mediated through activation of both mitochondria and caspases. 0000708209 00000 n h�b``a``?�����+�;����&0���3�2�X8�M`�� 0000697373 00000 n 0000785812 00000 n 0000751991 00000 n
Gamida Cell Announces Results from Phase 1 Study of GDA-201 and New Mechanism of Action Data at ASH 2019 Annual Meeting. The final cell therapy product may be cryopreserved until the patient is ready
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