and Q.F. PLoS One. You can also search for this author in 2020 Feb;15(2):1277-1293. doi: 10.2217/rme-2019-0086. Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: a double-blind, randomized, controlled trial.
In summary, these in vivo and ex vivo experiments demonstrated that TSG-6 and iPSC-MSCs promoted crypt epithelial cell proliferation via Akt activation.Based on the unique capability of MSCs to promote tissue repair, MSC treatment is a promising strategy to improve mucosal healing in IBD patients.
Pravastatin reverses obesity-induced dysfunction of induced pluripotent stem cell-derived endothelial cells via a nitric oxide-dependent mechanism. 2011;6(4):e19012.Gerami-Naini B, Smith A, Maione AG, Kashpur O, Carpinito G, Veves A, et al. ], as well as with the resources and the use of facilities at the VA Connecticut Healthcare System, West Haven, CT.The data that support the findings of this study are available from the corresponding author upon reasonable request.Vascular Biology and Therapeutics Program and the Department of Surgery, Yale School of Medicine, Yale University, 10 Amistad Street, Room 437, PO Box 208089, New Haven, CT, 06520-8089, USAJolanta Gorecka, Valentyna Kostiuk, Arash Fereydooni, Luis Gonzalez, Toshihiko Isaji, Shun Ono, Shirley Liu, Shin Rong Lee, Jianbiao Xu, Jia Liu, Ryosuke Taniguchi, Bogdan Yastula & Alan DardikSection of Cardiovascular Medicine, Department of Internal Medicine, Yale Cardiovascular Research Center, Yale School of Medicine, 300 George Street, Ste 773A, New Haven, CT, 06511, USASection of Plastic Surgery, Department of Surgery, Yale School of Medicine, Yale University, PO Box 208062, New Haven, CT, 06520-8062, USAYale Stem Cell Center, Yale University, New Haven, USAVascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, USADepartment of Pathology, Yale University, New Haven, USAYou can also search for this author in
S.Z., H.Y., R.F.
The effects of iPSC-MSCs is dependent on interactions between hyaluronic acid (HA) and CD44 in an Akt-dependent mannerIn the current study, we first evaluated the therapeutic efficacy of iPSC-MSCs in both TNBS-induced and DSS-induced murine colitis models. Induced pluripotent stem cells (iPSC) are an exciting cell type with enhanced therapeutic and translational potential. In this review, the cellular basis of scaring and fibrosis is examined. 2010;28(9):1568–70.Zhang Y, Wang D, Chen M, Yang B, Zhang F, Cao K. Intramyocardial transplantation of undifferentiated rat induced pluripotent stem cells causes tumorigenesis in the heart.
Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. They are reprogrammed into a pluripotent state in vitro by induced expression of four transcription factors including Oct4/Sox2/c-Myc/KLF4 or Oct4/Sox2/NANOG/LIN28 [Similar to embryonic stem cells, iPSC are pluripotent, have the potential for self-renewal, and can differentiate into any adult cell type.
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Baumgart, D. C. & Sandborn, W. J. An insight into non-integrative gene delivery approaches to generate transgene-free induced pluripotent stem cells. As our knowledge of the developmental and cellular basis of fibrosis increases, key targets to reduce scarring and fibrosis continue to emerge. Feng, R. et al. 2014;191:71–81.Rufaihah AJ, Huang NF, Jame S, Lee JC, Nguyen HN, Byers B, et al. This review focuses on the use of iPSC in animal models of wound healing including limb ischemia, as well as their limitations and methods aimed at improving iPSC safety profile in an effort to hasten translation to human studies. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers. This process is readily evident in the skin, but also occurs internally across organ systems in the form of fibrosis.
Induced pluripotent stem cells (iPSC) are an exciting cell type with enhanced … Wound healing is the physiologic response to a disruption in normal skin architecture and requires both spatial and temporal coordination of multiple cell types and cytokines. Mortality from ARDS ranges from 20% to 40%.Ischemic cardiovascular disease is the leading cause of death for adults worldwide.Peripheral vascular stenosis can also form secondary to fibrosis, most commonly at surgical anastomotic sites after either elective operations for vascular disease or surgical vascular repairs after traumatic injury. Biomaterials. ], the National Institutes of Health R01-HL128406 [A.D.], R01HL116705 and R01HL132130, DOD 11959515, and Connecticut’s Regenerative Medicine Research Fund [Y.Q. 2005;366(9498):1725–35.Frykberg RG, Zgonis T, Armstrong DG, Driver VR, Giurini JM, Kravitz SR, et al.
designed the experiments; H.Y., S.X., X.H.
TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds. You can also search for this author in & Dazzi, F. The immunomodulatory properties of mesenchymal stem cells. You are using a browser version with limited support for CSS. 2018;91(3):301–10.Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA. Diabetes Res Clin Pract. Panés, J. et al. The iPSC-MSC treatment promoted mucosal healing in colitic mice, accompanied by increased epithelial cell proliferation, CD44-positive cells, and Lgr5-positive cells. Available from: Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Major findings of studies relating to cutaneous wound healing in a murine model are outlined in Table Angiogenesis is a vital component of wound healing, as it reestablishes perfusion to injured tissues and delivers key nutrients. Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients.
10.1089/scd.2011.0649 [Google Scholar] Zhang M., Yang C., Liu H., Sun Y.
The recent discovery of human-induced pluripotent stem cells (iPSC) has revolutionized the field of stem cells. Some research protocols use mixtures of “progenitor‐type” cells rather than pure extracts of homogenous cells. 2018;13(10):e0205022.Foster AA.
Int J Biol Sci.
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